The experience of meaninglessness represents one of the most pervasive yet poorly understood psychological phenomena of contemporary life. This paper presents a comprehensive theoretical and empirical examination of the relationships between social detachment, alienation, and the experience of meaninglessness. Drawing upon classical sociological frameworks, contemporary psychological research, and existential therapeutic traditions, I argue that meaninglessness emerges not as an individual pathology but as a predictable psychological outcome of social detachment operating through multiple interconnected pathways. The analysis synthesizes evidence from social exclusion research demonstrating that rejection produces immediate cognitive deconstruction and meaninglessness, longitudinal studies identifying social connectedness as the strongest predictor of meaning in life, and clinical observations of existential neurosis. Four mechanisms are identified through which detachment generates meaninglessness: cognitive deconstruction following social exclusion, the erosion of normative frameworks, the loss of relational sources of meaning, and shame-mediated dissociative detachment. The paper concludes by examining therapeutic implications, particularly the potential of meaning-centered interventions to address the existential vacuum created by social detachment. This framework suggests that meaninglessness is best understood not as a philosophical problem to be resolved through individual reflection but as a social-psychological condition requiring reconnection and relational repair.