Background: Different studies proved that the homoeopathic medicine “Belladonna 200C” can abate the Japanese encephalitis virus infection in experimental models. The aim of this study is to find out the recent evidence based information which will be supportive to treat the Japanese Encephalitis virus infection according to severity of disease (JE) stratified in different stages. Methods: A review of important recent studies regarding the treatment of Japanese encephalitis was made and analyzed for extraction of newer ways of homoeopathic treatment in JE.A final protocol for treatment in different stages of JE was formulated accordingly. Results: After detailed analysis of all evidences, three homoeopathic medicines--Belladonna, Helleborus and Phosphorus were found specifically effective in three different stages according to severity and complications of the disease. Belladonna is useful in first stage of encephalitis without effusion. Helleborus is effective in the second stage of the disease with effusion, stupor, dragging of legs and developing paralysis. Finally the Phosphorus is indicated when complete paralysis appears due to inflammation and degeneration of brain cells. Conclusion: This new outlook of treatment may decrease mortality and morbidity of JE virus infection besides reducing the complication and disability rates.
