Health Sciences

Thoracic trauma frequently associated with morbidity and mortality. Rib fractures considered most common aetiology. The aim of the study is to determine the effectiveness of nerve block in rib fractures patients. Methods: During the period January 2017- January 2026 a retrospective study took place. Two hundred seventyeight (278) patients diagnosed already with rib fractures underwent nerve bock by thoracic surgery department(as outpatients at the emergency department and as patients already admitted) atGeneral Hospital of Nicaea-Piraeus, Greece.

This study assesses the current state of prosthetics and orthotics (P&O) rehabilitation services at the Komfo Anokye Teaching Hospital (KATH) under the Ghana Health Services (GHS) in Kumasi. The qualitative case study design enabled the exploration of infrastructure, human resources, logistics, and the overall quality of P&O services.

Drug repurposing, also known as drug repositioning or reprofiling, has emerged as a highly transformative strategy in modern pharmaceutical research, providing an efficient and economical alternative to traditional de novo drug discovery processes. Traditional drug development pipelines require 10 to 15 years and financial investments exceeding two billion dollars, while repurposingmakesefficient use of pre-existing clinical safety, pharmacokinetic, and toxicological profiles.

Ovarian enlargements cystic or solid ,may occur at any age. Functional and inflammatory enlargements of the ovary develop almost exclusively during reproductive age group. They may be asymptomatic or they may produce local discomfort, menstrual disturbances ,infertility or may acutely present as haemorrhage rupture or torsion .Ovarian mucinous cystadenomas are cystic lined by mucin producing epithelial cells.

Background: Cervical cancer remains a major public health concern in India despite being largely preventable through screening and human papillomavirus (HPV) vaccination. Delayed diagnosis, poor treatment compliance, and inadequate follow-up continue to compromise treatment outcomes, particularly in resource-limited settings. Clinical audits provide an opportunity to evaluate institutional practices, identify deficiencies in patient care, and guide quality improvement initiatives.

Background: Tonsillectomy remains one of the most frequently performed otorhinolaryngology procedures worldwide.Optimal surgical exposure during the procedure depends on specialized instruments such as maguaran plate and draffine bipod stand.The Maguaran plate and draffine bipod stand are indispensable tools for stabilizing the Boyle Davis month gag during tonsillectomy and similar Ear, Nose and threat (ENT) procedures.

Background: Open simple prostatectomy (OSP) remains a valuable surgical option for patients with benign prostatic hyperplasia (BPH) in developing countries, especially patients with significantly enlarged prostate. Uroflowmetry, a non-invasive urodynamic test, plays a key role in both pre-operative assessment and post-operative evaluation of such patients. This study examined the role of uroflowmetry in outcome measure following OSP and explores the clinical implications of these measures.

Objectives: Over time, there has been a development in veneer materials, changes in preparations, and improvements in veneer cementation. Multiple research have assessed the impact of coffee on various physical characteristics of both direct and indirect veneers, as well as the materials utilized in their fabrication. The attribute of veneers that has received the most extensive research is their color stability. This systematic review aimed to study the effect of coffee as a beverage on color stability of direct and indirect veneers.

Immune checkpoint inhibitors (ICIs) have transformed oncological practice by generating durable antitumour responses across a broad spectrum of malignancies. However, meaningful clinical benefit accrues to only a fraction of patients, and resistance remains a persistent challenge. This review examines the evolution of ICI-based therapy from single-agent checkpoint blockade through multimodal combination regimens to biomarker-directed, personalised strategies.

Triple negative breast cancer (TNBC) represents a clinically aggressive form of breast carcinoma distinguished by the lack of estrogen, progesterone, or HER2 receptors, which limits therapy options and poorer prognosis. This subtype exhibits considerable heterogeneity and is driven by multiple molecular signaling networks mTOR, Wnt, Notch, and NF-kB. Chemotherapy is primary treatment strategy, although new targeted treatment options and immunotherapies, including PARP and immune checkpoints, are polyphenols and flavonoids which can alter cancer pathways.