Health Sciences

Objectives: Over time, there has been a development in veneer materials, changes in preparations, and improvements in veneer cementation. Multiple research have assessed the impact of coffee on various physical characteristics of both direct and indirect veneers, as well as the materials utilized in their fabrication. The attribute of veneers that has received the most extensive research is their color stability. This systematic review aimed to study the effect of coffee as a beverage on color stability of direct and indirect veneers.

Immune checkpoint inhibitors (ICIs) have transformed oncological practice by generating durable antitumour responses across a broad spectrum of malignancies. However, meaningful clinical benefit accrues to only a fraction of patients, and resistance remains a persistent challenge. This review examines the evolution of ICI-based therapy from single-agent checkpoint blockade through multimodal combination regimens to biomarker-directed, personalised strategies.

Triple negative breast cancer (TNBC) represents a clinically aggressive form of breast carcinoma distinguished by the lack of estrogen, progesterone, or HER2 receptors, which limits therapy options and poorer prognosis. This subtype exhibits considerable heterogeneity and is driven by multiple molecular signaling networks mTOR, Wnt, Notch, and NF-kB. Chemotherapy is primary treatment strategy, although new targeted treatment options and immunotherapies, including PARP and immune checkpoints, are polyphenols and flavonoids which can alter cancer pathways.

The expansion of local resources is one of the greatest challenges to food security in Africa. Among these, the pulp of the R. sese De Wild fruit is practically considered an important staple food in certain communities. The objective of this study is to assess consumption patterns, sociodemographic indicators, and perceptions of this pulp in the city of Kikwit. A descriptive and analytical cross-sectional study was conducted on 320 households selected through stratified sampling.

Cancer remains one of the leading causes of mortality worldwide, and the overexpression of Epidermal Growth Factor Receptor (EGFR) plays a critical role in tumor progression, proliferation, angiogenesis, and metastasis. The present study aimed to investigate the anticancer potential of luteolin, a naturally occurring flavonoid, through molecular docking and in vivo experimental tumor evaluation targeting EGFR. Molecular docking studies were performed to evaluate the binding affinity and interaction of luteolin with the active site of EGFR protein.

The process of wound healing is a complicated physiological undertaking that includes inflammation, proliferation, and the remodeling of tissue. Oxidative stress, decreased angiogenesis, microbial infection, and reduced collagen synthesis are all factors that contribute to the considerable delay in wound healing that is associated with diabetes mellitus. The use of herbal medicines as alternative therapeutic agents has become more popular due to the fact that they are not only safe but also affordable and have pharmacological action that targets several targets.

The World Health Organization defines antenatal care as the care provided by skilled healthcare professionals to pregnant women and adolescent girls to ensure optimal health outcomes for both the mother and the developing fetus throughout pregnancy. Appropriate antenatal care plays a crucial role in safeguarding maternal health and promoting normal fetal growth and development, thereby influencing the health of future generations.

The present Decision-making is a fundamental cognitive process that underlies nearly every domain of human behaviour. The present study examined the psychological foundations of decision-making by investigating the contributions of personal values and moral reasoning to rational and intuitive decision-making styles. A sample of 201 emerging adults completed standardised questionnaires measuring decision-making style, value orientations, and moral reasoning capacity. Correlation and regression analyses were employed to examine the relationships among these variables.

Introduction: Premenstrual Syndrome (PMS) is a prevalent cyclical gynecological condition characterized by recurrent physical, psychological, and behavioral symptoms that occur during the luteal phase of the menstrual cycle and subside with the onset of menstruation. Although PMS is not described as a distinct disease entity in Unani medicine, its symptom complex closely corresponds to conditions such as Ihtebās-e-Ṭams (retention of menses), Sudāʿ Qabl al-Ḥayḍ (premenstrual headache), and Tashannuj al-Raḥim (uterine spasm).

Horse purslane (Trianthema portulacastrum L.) is considered the most troublesome agricultural weed in tropical and sub-tropical areas of the world, including the US, Mexico, Northern and Southern states of India and Pakistan by virtue of its infestation in various vegetable and agricultural fields. Foliar phytopathogenic fungi, the fungi that cause foliage diseases in plants, offers a tremendous opportunity to develop as bioherbicides/mycoherbicides.