Background:Patients post colectomy experience a substantial decline fitness level and quality of life. As obesity is one of the most important risk factors for colorectal cancer, studies show that aerobic exercises and weight loss program will result in reduction of leptin and increase of ghrelin in patients with colorectal cancer. Objectives: was to investigate plasma leptin and ghrelin concentrations in male patients with colorectal cancer post colectomy after 8 weeks of aerobic exercise and a week of detraining. Materials and Methods: A cross-sectional observational study was conducted on thirty men selected from surgery department at Minia University Hospital (Egypt). They were assigned randomly into two equal groups each group was 15 patients, their age ranged from 50-60 years. Patients were evaluated by rockportwalking test using (treadmill), Fazzini weight scale and fasting blood plasma test using (ELISA kit) before and after the study. The study group (A) received aerobic training for 8 weeks as 3 sessions /week each session last for 45 minutes and control group (B) were only advised about healthy lifestyle. Results: The results showed that heart rate was decreased and VO2peak was increased in the training group compared to the control group (P < 0.05). Ghrelin concentration was increased significantly in the training group compared to the control group (P < 0.05), while plasma leptin hormone did not change significantly after training for both groups. Conclusion: The study concluded that aerobic training increases ghrelin hormone levels VO2peak after 8 weeks of aerobic exerciseand a week of detraining however, plasma leptindose not affected by this protocol in male patients with colorectal cancer.
