Transcription factor binding site prediction: tools, techniques, and applications
Transcription factors (TFs) are pivotal regulatory proteins thatbind to DNA sequences called transcription factor binding sites (TFBSs) to regulate the expression of genes. When, where, and how genes are active or repressed are all fundamentally determined by these binding sites. An overview of the biological significance of TFBSs, their role in gene regulation, and the consequences of their failure in disease are given in this article.